Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells

To quantify rare tumor markers that will allow oncologists to make prognoses and select therapies, John X.J. Zhang, PhD led a team of bioengineers from Thayer School of Engineering at Dartmouth in demonstrating a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells (CTCs). The microscale immunoassay can be further interfaced with a fluorescent microscope for cancer cell imaging. Their paper, “Microscale Magnetic Field Modulation for Enhanced Capture and Distribution of Rare Circulating Tumor Cells,” was published in Scientific Reports, Nature Publishing Group.

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